Development of BCG Scar and Subsequent Morbidity and Mortality in Rural Guinea-Bissau

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Development of BCG Scar and Subsequent Morbidity and Mortality in Rural Guinea-Bissau.

BACKGROUND Previous studies have found that BCG vaccination has nonspecific beneficial effects on child survival, especially among children who developed a BCG scar. These studies have mostly been done in settings with a high scar frequency. In rural Guinea-Bissau, many children do not develop a scar; we tested the hypothesis that among BCG-vaccinated children, a vaccination scar was associated...

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Seasonal variation in child mortality in rural Guinea‐Bissau

OBJECTIVES In many African countries, child mortality is higher in the rainy season than in the dry season. We investigated the effect of season on child mortality by time periods, sex and age in rural Guinea-Bissau. METHODS Bandim health project follows children under-five in a health and demographic surveillance system in rural Guinea-Bissau. We compared the mortality in the rainy season (J...

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BCG vaccination scar associated with better childhood survival in Guinea-Bissau.

BACKGROUND Recent studies have suggested that Bacille Calmette-Guerin (BCG) vaccination may have a non-specific beneficial effect on infant survival and that a BCG scar may be associated with lower child mortality. No study has previously examined the influence of BCG vaccination on cause of death. METHODS Two cohorts (A and B) were used to describe the mortality pattern for children with and...

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Effect of revaccination with BCG in early childhood on mortality: randomised trial in Guinea-Bissau

OBJECTIVE To determine whether BCG revaccination at 19 months of age reduces overall child mortality. DESIGN Randomised trial, with follow-up to age 5. SETTING A health project in Bissau, Guinea-Bissau, which maintains a health and demographic surveillance system in an urban area with 90 000 inhabitants. PARTICIPANTS 2871 children aged 19 months to 5 years with low or no reactivity to tub...

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ژورنال

عنوان ژورنال: Clinical Infectious Diseases

سال: 2015

ISSN: 1058-4838,1537-6591

DOI: 10.1093/cid/civ452